ABSTRACT
The purpose of this article was to review current literature on the usage of denture bases as potential drug-release devices DRDs] for the treatment of oral conditions such as Candida associated denture stomatitis [CAD] and recurrent ulcers. Relevant publications from the year 1983 to 2014 were included by searching 'denture bases' and 'drug delivery' using [MeSH terminology]. Specific inclusion and exclusion criteria were set. Most studies were done in vitro. It was concluded during the review that various therapeutic agents such as Fluconazole, Chlorhexidine gluconate and Hydrocortisone Sodium Succinate have been successfully incorporated in denture base resins. Drugs leach out steadily from poly methyl methacrylate [PMMA] specimens for a period of 28 days. In case of rechargeable denture bases, the elution continues for longer periods. A lot of ongoing research is being done on the incorporation of silver nanoparticles and monitoring its antimicrobial activity
ABSTRACT
Aglossia is a rare malformation resulting in the partial development or complete absence of the tongue. It is commonly associated with craniofacial and limb defects [Oromandibular Limb Hypogenesis Syndrome].The etiology is unknown and various theories have been proposed for this. The objective of presenting the case report and literature review is to discuss the clinical presentation, causative factors and possible management strategies of this rare malformation